The Clinical Research Centre Hospital Tuanku Jaafar Seremban (CRC HTJ) was established in September 2006. It is part of the Ministry of Health (MOH) Clinical Research Centre Network set up under the National Institute of Health (NIH). The CRC network was set up in line with the vision of the Ministry of Health to make research one of the important key activities at MOH.

CRC HTJS serves as a local coordination centre for research activities, clinical registry and training related to research.