Clinical Research Centre
Hospital Tuanku Ampuan Rahimah
Klang, Selangor
WhoWe Are
The Clinical Research Centre Hospital Tengku Ampuan Rahimah (CRC HTAR) Klang was established in September 2006. Located in the main building of HTAR, the CRC aims to serve as a one-stop research center to meet all clinical research needs. Initially staffed by a head of unit, an admin manager, a nurse, and a research assistant, the center has grown since its inception. Currently, CRC HTAR is led by Dr. Norleen Zulkarnain Sim, a Nephrologist and is recognized as one of the prime sites for clinical trials under the Institute of Clinical Research (ICR), Malaysia. The center’s coverage extends to Tengku Ampuan Jemaah Hospital in Sabak Bernam, Banting Hospital, and the Klang and Kuala Langat District Health Offices. Despite its growth, the center maintains its commitment to ethical and quality clinical research, aiming to improve patient health outcomes. The CRC's vision is to become the leading clinical research institution in the state, encapsulated by its tagline, "Research that Matters to Patients."
OurTeam
InvestigatorsHighlight
Head of CRC, Consultant Nephrologist Hospital Tengku Ampuan Rahimah, Klang
Email: oleen@me.com
MBBS (University of London, UK), MRCP (UK), FRCP (Edin), Malaysian Board of Nephrology
Areas of interest: Critical Care Nephrology, Chronic Kidney Disease, Lupus Nephritis, Clinical Trials and Research
Awards & achievements:
- MultiplNational Postgraduate Medical Curriculum (NPMC) of Internal Medicine certified as Supervisor - 2022
- Good Clinical Practice NIDA Clinical Trial Network - 2019, 2011
- National Specialist Register (NSR): Internal Medicine and Nephrology
- Good Clinical Practice (GCP) - 2000
Dr. Norleen is a Consultant Nephrologist with a career spanning over two decades. Since 2007, she has been a cornerstone in the Nephrology Department at Hospital Tengku Ampuan Rahimah (HTAR) Klang, Malaysia with a particular focus on critical care nephrology in recent years. Dr. Norleen has made significant contributions to nephrology research, serving as the Site Principal Investigator for numerous clinical trials since 2005. Her leadership in studies like the VALOR-CKD and CARMELINA trials has advanced the understanding and treatment of chronic kidney disease, lupus nephritis, and Type 2 Diabetes Mellitus, influencing global clinical practices. In addition to industry-sponsored research, she has led various investigator-initiated studies, presenting her findings at esteemed conferences such as the World Congress of Nephrology.
Research Highlights
- Encounters and outcome of Catheter related bloodstream infections (CRBSI) among haemodialysis patients from private dialysis centres in Hospital Tengku Ampuan Rahimah.
- Nephrologist initiated peritoneal dialysis catheter insertion in patients with extended criteria
- Cancellation of elective daycare Tenckhoff Catheter insertion in Hospital Tengku Ampuan Rahimah: rates and factors
- CARMELINA: a multicentre, international, randomized, parallel group, double-blind, placebo-controlled cardiovascular safety and renal microvascular outcome study with Linagliptin 5mg once daily in patients with Type 2 Diabetes Mellitus at high vascular risk
- BI Lupus 1293.13: An exploratory maintenance trial evaluating the effect of BI 655064 in Lupus Nephritis patients who have achieved a meaningful response either at the end of 1293.10 or after an induction treatment outside of 1293.10
- VALOR-CKD: A Phase 3b, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of TRC101 in delaying Chronic Kidney Disease progression in subjects with metabolic acidosis
- BAXDUO ARCTIC: a phase III, randomised, double-blind, active-controlled study to assess the efficacy, safety and tolerability of baxdrostat in combination with dapagliflozin compared to dapagliflozin alone on chronic kidney disease (CKD) progression in participants with CKD and high blood pressure
Recent Publications
Project Highlights
| NMRR-16-2814-29003 | Multi-Center Field Trial Of A Diagnostic Kit For The Identification Of Potential Severe Dengue |
Meet Our Collaborators
Further info on upcoming activities
CRC Hospital Tengku Ampuan Rahimah, Klang, Selangor
Main Phone: +603-33757000 ext. 1546
Email: crcklanghtar@moh.gov.my
